ABSTRACT
Shweta Pradara or excessive vaginal discharge is one of the commonest complaints among women of reproductive age group. An increase in the normal vaginal secretion develops physiologically at puberty, at ovulation, premenstrual phase and during pregnancy. Excessive discharge causes irritation and itching in the genetalia. Ayurveda explained this condition as Shweta Pradara. Shweta Pradara is a symptom which is present in most of the diseases or present as a complication. Shweta Pradara is not a disease it produces as a symptom, hence etiopathogenesis of principal disease and Shweta Pradara would be same. It is a Kaphaja disorder at the place of Apana Vayu. A 47 years old female patient suffering from intermittent Yonigata Shwet Strava since two years with aggravation of symptoms from one week presented to Prasuti Tantra Evam Stree Roga OPD. Yonigat Shwet Strava was associated with Yoni Kandu, Katishool, Yoni Daha. On enquiry, it was found that she was the known case of Type II Diabetes Mellitus since 10 years. She was taking medication for the same but her blood sugar levels were uncontrolled in spite of taking medication as per her recent investigations. In this case Shwet Pradar was the Updrava of Madhumeh, thus line of management was planned to control her sugar level by supplementing Ayurvedic drugs along with allopathic medicine for DM II (Madhumeh) and treated her with Yoniprakshalan with Triphala Kwath followed by Cutis ointment tamponing per vaginum for 14 days. She had followed the schedule of Yoni Prakshalana, oral medicines and Pathya-Apathya properly. It was observed that, symptoms were started to reduce gradually which has been depicted by documentation of investigations and local examination in this case study.
ABSTRACT
Asrigdar has been characterised by excessive bleeding per vaginum. Acharya Charaka described Asrigdar as a separate disease along with its treatment in Yoni Vyapada Chikitsha Adhyaya. Acharya Charaka also described it as a Raktaja Vikara. Acharya Sushruta described Asrigdar due to Pitta Samyukt Apana Vayu. It can be correlated with Abnormal Uterine bleeding in modern. Any uterine bleeding other than normal duration, frequency and volume is considered as abnormal uterine bleeding. It affects about 30% of women in reproductive period. It is often associated with backache, pain in lower abdomen and weakness. A 23 years old female patient presented with complaints of Irregular menses with excessive bleeding per vaginum associated with pain lower abdomen. On further enquiry it was found that she had irregular menses since menarche. She took modern treatment but didn’t get significant relief. Due to excessive bleeding she had Anaemia also. Keeping all the aspects in mind a treatment has been planned. Doshas involved in Asrigdar are mainly Pitta and Vata, That is why, for Samprapti vighatan basic treatment divided into three parts i.e. Shaman chikitsha along with Sthanik chkitsha over abdomen with Krishna Mritika and Basti chikitsha. Shaman chikitsha which includes Pitta and Vata shamak, Raktastambhaka and Balya Aushadh. In Bhavprakash Nighantu Krishna Mritika has been kept in Ashtama Dhatwadi Varga and mentioned in Rakta Pradra or Rakt Vikara. The treatment protocol was followed for three cycles with positive outcome as better cycle control and symptomatic improvement in this patient.
ABSTRACT
Nutrigenomics is an emerging branch of science that creates foundation of the relationship between nutrients from diets and their effects on expression of genomes. It also encompasses the heterogenous response of gene to different nutrients, dietary components and developing nutraceuticals under the heading of nutrigenetics. Exploring the aspects of nutrigenomics has been conceptualised to develop the approaches for the determination of the etiology of different physiological conditions, pathological conditions alongside the management of different morbidities by application of the dietics and also prevention of certain possible gene expression causing morbid conditions. All these facts that diet plays in determination of health or disease have already been mentioned in the ancient times by the scholars of Ayurveda. Ayurgenomics in other side includes of classical facts that has been mentioned in the Ayurvedic classic texts which clearly mentions that the Aahar determines the state of health and diseased conditions in an individual. It determines the individuality in the requirement of the nutritional sources in all different individual is different and unique. When the nutrition for the individual is personalised determining the Prakriti (constitution) of the individual, this will ensure maintaining the health and resolving the diseases in the subject. Also different forms of incompatible combinations of Aahar have also been mentioned in Ayurveda and their different levels of effects in different individual have been described under the topic of Virruddhaahar. Analytical study of these subjects together could be manifested in the management of different pathological conditions or even for the prevention of the disease condition in the field of disease management
ABSTRACT
Background/Aims@#Existing therapeutic options for complicated Crohn’s disease (CD) like biologics and surgery are limited by inadequate long-term efficacy, cost, and adverse effects. Tissue hypoxia is important in CD pathogenesis and may be ameliorated with hyperbaric oxygen therapy (HBOT). We assessed the efficacy and tolerability of HBOT in small bowel stricturing CD. @*Methods@#This pilot study included patients of small bowel stricturing CD (from April 2019 to January 2020) who underwent HBOT. These patients were refractory to conventional medical treatment or had multiple strictures not amenable to resection. Each session of HBOT was given for 60 minutes with a pressure of 1.5–2.5 atm. Clinical, biochemical responses and Short Inflammatory Bowel Disease (SIBD) questionnaire were evaluated at 2 and 6 months, and radiological response was evaluated at 6 months. @*Results@#Fourteen patients (mean age, 42.9±15.7 years; male, 50%) were subjected to 168 HBOT sessions. Thirteen patients (92.7%) had strictures and 1 patient had enterocutaneous fistula in addition. Median number of HBOT sessions was 11 (range, 3–20) which were administered over a median of 4 weeks. Most patients tolerated it well except 1 who had hemotympanum. At 2 and 6 months of follow-up, 64.2% of patients had a clinical response, 50% and 64.2% of patients had clinical remission respectively. Steroid-free clinical remission was seen in 8 (57%) of patients with radiological improvement in 50%. There was a significant improvement in SIBD scores at 2-month follow-up (59.4 vs. 44.5, P=0.03). @*Conclusions@#HBOT can be a safe and effective therapeutic option in patients with stricturing small bowel CD refractory to conventional medical treatment.
ABSTRACT
Posterior reversible encephalopathy syndrome [PRES] is a rare clinicoradiological entity characterized by neurological symptoms. It is associated with various conditions like hypertension, renal diseases and use of cytotoxic agents. It occurs more often in adults than children. PRES has been described in pediatric patient with renal diseases like nephrotic syndrome, nephritis and in acute renal failure as in cases of Hemolytic-uremic syndrome but there are no reports of PRES in cases of recovery from acute kidney injury due to prerenal cause like hypovolemia. We herein present an interesting case of 6-year-old girl with traumatic amputation who developed PRES days after recovery of acute kidney injury. The patient was successfully managed medically. The presented clinical scenario demonstrates the fact that PRES can develop in a trauma patient in acute setting of recovering from hypovolemic acute kidney injury. Prompt recognition and treatment is important and can lead to complete recovery